Premise: When astronaut John Crichton was accidentally shot through a wormhole, he didn't just end up on the other side of the galaxy -he ended up stuck in the middle of a space battle. Three prisoners -D'Argo, a Luxan warrior framed for the murder of his Sebacean wife; Zhaan, a Delvian priestess jailed for the brutal murder of her lover; and Rygel, a deposed monarch of the Hynerian Empire out for revenge against the cousin who betrayed him and took his throne -were escaping their confinement aboard a living ship named Moya.

Officer Aeryn Sun, a loyal Peacekeeper commando pilot, was among those trying to stop them. By the end of the day, the prisoners were free, Aeryn had been exiled from her people, and Crichton was a fugitive. These strangers sre forced to work together to survive. Aeryn's former commanding officer, Captain Bialar Crais, hunted them through the dangerous Uncharted Territories for many months.

As time went on, Crichton continues his quest to find a wormhole back home, whilst holding off the evil machinations of the half Sebacean/half Scarran torturer Scorpius whose determined to find wormhole technology and believes the key lies in alien memories implanted into John's brain. The hunt is on.