Cast: Grant Bowler, Julie Benz, Stephanie Leonidas, Tony Curran, Jaime Murray, Graham Greene, Mia Kirshner
- Airs: 9pm Mondays
- Air Dates: April 2013 - Still Running...
Set in the year 2046, Earth has been radically transformed, causing changes in topography, the extinction of plant and animal species, and the emergence of new species. The series follows Joshua Nolan and his adopted Irathient daughter Irisa, who have put down roots in Defiance, a city-state community where humans and several extraterrestrial races, collectively known as Votans, coexist over the ruins of St. Louis.