Reese Witherspoon, Hugh Laurie, Will Arnett, Seth Rogen, Stephen Colbert, Rainn Wilson, Kiefer Sutherland and Paul Rudd will all be voicing characters in DreamWorks Animation's 3D "Monsters vs. Aliens" reports the trades.

The story reinvents the classic '50s monster movie as a modern-day action comedy and centers on California girl Susan Murphy (Witherspoon), who is unexpectedly clobbered by a meteor full of outer space gunk and mysteriously grows to 50 feet tall.

She is captured and held in a secret government compound. The world learns that the military has been quietly rounding up other monsters over the years, including the brilliant but insect-headed Dr. Cockroach, Ph.D. (Laurie) and macho half-ape, half-fish the Missing Link (Arnett).

Wilson plays the evil alien warlord Gallaxhar, Colbert is the US President, Sutherland is General W.R. Monger and Rudd is Susan's boyfriend, Derek. Rob Letterman ("Shark Tale") and Conrad Vernon ("Shrek 2") will helm.