Jennifer Connelly, Kevin Connolly, Bradley Cooper, Justin Long and Ginnifer Goodwin are in negotiations to star in the ensemble comedy "He's Just Not That Into You" for New Line Cinema says The Hollywood Reporter.

Based on "Sex and the City" scribes Greg Behrendt and Liz Tuccillo's best-selling book, the tome serves as a social commentary about modern-day relationships and how men and women often misconstrue the intentions of the opposite sex.

The Baltimore-set movie of interconnecting story arcs has Jennifer Connelly playing a woman stuck in a tired marriage with Cooper's character. Kevin Connolly, is a man pining after a woman who is having an affair with Cooper.

Goodwin is a young woman obsessed with Kevin Connolly's character who tries to set up accidental meetings with him only to run across his friend, played by Long, who takes her on as a "My Fair Lady" experiment.

Drew Barrymore is set to produce and play a woman perpetually confused by dating, now more than ever in a culture that is more obsessed with technology than actual human contact.

Abby Kohn and Marc Silverstein penned the adaptation, and Ken Kwapis is directing. Production is due to start early September in Los Angeles.