Matthew Broderick, Virginia Madsen and Alan Alda have signed on to star in "Diminished Capacity," a comedy about family and memory loss produced by Gotham-based Plum Pictures reports Variety.

Terry Kinney, who starred in and also directed several episodes of "Oz," is directing the pic. Sherwood Kiraly is penning the screenplay based on his novel of the same name.

Broderick will play the lead role, a man who suffers memory loss after getting hit on the head. He then takes a trip with his Alzheimer's-addled uncle (Alda) and his high school sweetheart (Madsen) to a memorabilia show as the group concocts a scheme to sell a rare baseball card.

Bobby Cannavale and Lois Smith are also attached to star. Shooting begins this spring in New York and Chicago.