Ira Steven Behr, co-creator of "The 4400" told SCI FI Wire to expect a new direction in the show's upcoming third season that will focus more on the show's mythology and main characters.

"We are definitely using the last two episodes of last season, 'The Fifth Page' and 'Mommy's Bosses,' as the engine to drive this season. In other words, last year we kind of alternated kind of big mythology type of episodes ... [with episodes in which] we'd introduce [new members of] the 4400. What we're going to be focusing on basically this season [is] bigger sweep... I think every story this year will have an impact on our people".

In a spoiler for the upcoming season, Behr also said that Megalyn Echikunwoke would join the cast, playing an adult version of baby Isabelle - "Isabelle is no longer that cuddly kid you can hold in your arms. The character herself, I think, is going to surprise people... It's going to be more of a ride, more of a discovery, and not so clear-cut where you can say, 'She's the angel' [or] 'She's the devil,' you know? And I think that makes for really nice storytelling".

The 4400 returns with 13 new episodes, starting June 4th.