Samuel L. Jackson is in talks to star in "Flight 121," a New Line thriller that will start production in May. David Ellis, who helmed "Final Destination 2" and "Cellular" for New Line, will direct reports Variety.

Jackson plays an FBI agent on a long quest to bring a ruthless mob boss to justice. He finds a witness and takes him on a commercial flight from Hawaii to L.A. Trouble is, the mob boss has loaded the cargo with all kinds of venomous snakes.

Pic was originally scripted by John Heffernan and most recently rewritten by Sebastian Gutierrez ("Gothika"). Jackson is about to start work in the Joe Roth-directed "Freedomland" opposite Julianne Moore.

Thanks to 'Yes Rory, I Meant Your Cliff'