Marvel's new CEO Kevin Feige recently told MTV News that "Spider-Man 3" is certainly not the end for that venerable film franchise.
"There will be many more Spider-Man films to come. We already have stacks of ideas for the next one because of the wealth of stories in the comics. We could be making Spider-Man movies for the next 20 years, based on the 50 years of Spider-Man history we have"
Will the same people be involved though? He was more cryptic on that front - "When you're concentrating on one movie at a time, there's a beginning and a middle and an end to that process. We've been topping each one as they go, [and if that happens again], that's the time for those discussions".