A couple of quotes from Harvey Weinstein have given an indication as to where the "Scream" franchise might be going next.
Harvey and his brother Bob Weinstein have expressed interested in a fifth film in the series. Attending the Zurich Film Festival, Harvey told Indiewire: "Everyone lived in Scream 4. I'm begging him [Bob] to do the movie and just end it. We’ve milked that cow."
There's also that "Scream" TV series in development at MTV, and BlairWitch.de has details from Weinstein which indicates the show and the existing film series won't overlap.
On top of that, the show "is supposed to represent a new beginning and also pursue a supernatural direction." Jay Beattie and Dan Dworkin ("Revenge") are penning the series.