Quaid will play General Hawk, the grizzled team leader. Tatum will play Duke Hauser, the lead soldier of the G.I. Joe crew. Vosloo will play Zartan, a mercenary who works with Destro and Cobra.
Tatum's role was originally to be played by Sam Worthington who had to pull out due to scheduling conflicts with James Cameron's "Avatar."
The trio joins Sienna Miller, Ray Park, Rachel Nichols, Marlon Wayans, Adewale Akinnuoye-Agbaje, Said Taghmaoui and Joseph Gordon-Levitt in the live action film, which is set in the future and based on the popular Hasbro action figures.
Stephen Sommers is directing from the latest script penned by Stuart Beattie. The film is scheduled for an August 7th, 2009 release.