- Cast: Adrien Brody, Sarah Polley, David Hewlett, Abigail Chu, Delphine Chanéac, Stephanie Baird, Brandon McGibbon, Amanda Brugel
- Director: Vincenzo Natali
- Writers: Vincenzo Natali, Antoinette Terry Bryant, Doug Taylor, Vincenzo Natali, Antoinette Terry Bryant
- Producer: Steven Hoban
- Executive Producers: Franck Chorot, Susan Montford, Christophe Riandee, Guillermo del Toro, Marco Weber
- Art Direction: Joshu de Cartier
- Castings: John Buchan, Constance Demontoy, Jason Knight
- Costume Design: Alex Kavanagh
- D.O.P.: Tetsuo Nagata
- Editor: Michele Conroy
- Makeup: Marie Nardella
- Music: Cyrille Aufort
- Production Design: Todd Cherniawsky
- Set Decoration: Liesl Deslauriers
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
- Aspect Ratio: 1.85:1
- Filming Locations: Toronto, Canada
- MPAA Warning: Disturbing elements including strong sexuality, nudity, sci-fi violence and language
- Production Budget: $26 million
- Production Companies: Gaumont, Copperheart Entertainment
- Production Schedule: 3 December 2007 - 28 February 2008
2010 Guide Analysis: "Cult Canadian genre film director Vincenzo Natali ("Cube," "Cypher") returns with this strange cautionary tale fusing themes of genetic engineering out of control with the anxiety of young parenthood. The result is something along early David Cronenberg lines, using the gory and grotesque for larger emotional and psychological metaphors its central characters explore which in this case cross the nature/nurture divide.
The star though is the creature itself, a combination of computer effects, make-up prosthetics and a practical girl in a suit - the result is something both convincingly real and very eerie, like the offspring of an orgy between a praying mantis, a cantaloupe, and an Icelandic supermodel. Solid thesps Brody and Polley as the doting scientists/parental figures should make for a strong combination, while Natali's involvement and foreign money means this pushes a lot of boundaries that Hollywood studio films dare not, from the grossness of the biology to a very strong and graphic amount of strange sexuality ("Chimeras Gone Wild").
Reviews out of the Stiges Film Festival in November called it Natali’s best film since "Cube", though admit the pacing is somewhat too deliberate (i.e. slow) for horror fans. There's also sadly talk of editors coming in and cutting back on a lot of the harder-edged elements for the American theatrical release which means this is one of those films that it's best to probably wait for the import DVD. More reviews to come out of Sundance in a few weeks may affect that, we'll see."