- Cast: Robert Downey Jr., Jude Law, Rachel McAdams, Mark Strong, Kelly Reilly, Eddie Marsan, Robert Maillet, James Fox, Hans Matheson, Robert Stone, William Hope, William Houston, David Garrick, Terry Taplin
- Director: Guy Ritchie
- Writers: Guy Ritchie, Tony Peckham, Mike Johnson, Simon Kinberg
- Producers: Susan Downey, Dan Lin, Joel Silver, Lionel Wigram
- Executive Producers: Bruce Berman, Steve Clark-Hall
- Art Directions: James Foster, Matthew Gray, Niall Moroney
- Casting: Reg Poerscout-Edgerton
- Costume Design: Jenny Beavan
- D.O.P.: Philippe Rousselot
- Editor: James Herbert
- Makeup: Christine Blundell
- Production Design: Sarah Greenwood
- Set Decoration: Katie Spencer
Robert Downey Jr. brings the legendary detective to life as he has never been portrayed before. Jude Law stars as Holmes' trusted colleague, Watson, a doctor and war veteran who is a formidable ally for Sherlock Holmes. Rachel McAdams stars as Irene Adler, the only woman ever to have bested Holmes and who has maintained a tempestuous relationship with the detective. Mark Strong stars as their mysterious new adversary, Blackwood. Kelly Reilly will play Watson's love interest, Mary.
- Aspect Ratio: 1.85:1
- Filming Locations: Kent, England; London, England; Manchester, England
- Production Companies: Lin Pictures, Silver Pictures, Village Roadshow Pictures, Wigram Productions
- Production Schedule: 3 October 2008 -
- Colin Farrell was in talks to play Watson before Jude Law was cast.
- The first Sherlock Holmes film to reach U.S. movie theaters in over twenty years, since the 1988 comedy Without a Clue (1988) with Michael Caine as Reginald Kincaid/"Sherlock Holmes".
- While filming a fight scene, Robert Maillet accidentally knocked out Robert Downey Jr.
- Robert Downey Jr. read many Sherlock Holmes stories and watched 'The Adventures of Sherlock Holmes (1984)' by Granada Television (starring Jeremy Brett) in order to learn more about the character.
- Jude Law had an early role in "The Casebook of Sherlock Holmes" (1991) Shoscombe Old Place. This was the series featuring Jeremy Brett, and is a favorite adaptation among Sherlock Holmes fans.